Fenofibrate, statins, and inflammation.
نویسنده
چکیده
To the Editor: I recently read the review by Berg et al, about tissue, inflammation, and cardiovascular disease.1 Although the review discusses our research on ligands for peroxisome proliferator activated receptor (PPAR), we used fenofibrate, a PPARactivator, not glitazones, PPARagonists, as the review suggests.2 We also found that statins non-significantly lower serum adiponectin levels, not as the review states that statins marginally increase adiponectin levels.3
منابع مشابه
Belgian expert opinion: how to reduce the residual risk in atherogenic dyslipidaemic patients: place of fibrates.
The demographics of dyslipidaemia have changed towards a more complex atherogenic dyslipidaemia involving increased levels of LDL-C, in particular highly atherogenic small dense particles, hypertriglyceridaemia and low HDL, together with increased levels of markers of cardiovascular inflammation, thrombogenesis and endothelial dysfunction. Statins were shown to significantly lower cardiovascula...
متن کاملHepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein.
Dyslipidemia and inflammation play an important role in the pathogenesis of cardiovascular and liver disease. Fenofibrate has a well-known efficacy to reduce cholesterol and triglycerides. Combination with statins can ameliorate hypolipidemic and anti-inflammatory effects of fibrates. In the current study, we tested the anti-inflammatory and metabolic effects of fenofibrate alone and in combina...
متن کاملPleiotropic Effects of Atorvastatin and Fenofibrate in Metabolic Syndrome and Different Types of Pre-Diabetes
OBJECTIVE To compare extra-lipid effects of statins and fibrates in relation to the baseline metabolic status of patients. RESEARCH DESIGN AND METHODS The study involved a group of 242 metabolic syndrome patients with or without pre-diabetes and randomized to atorvastatin, fenofibrate, or placebo. RESULTS Compared with matched healthy subjects, metabolic syndrome patients exhibited higher p...
متن کاملCell Biology/Signaling Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs
Objectives—Statins and fibrates are hypolipidemic drugs which decrease cardiac events in individuals without raised levels of cholesterol. These drugs inhibit platelet function, but the mechanisms by which this pleiotropic effect is exerted are not known. Methods and Results—We used a range of approaches to show statins inhibit human platelet activation in vitro while engaging PPAR and PPAR . T...
متن کاملAntiplatelet actions of statins and fibrates are mediated by PPARs.
OBJECTIVES Statins and fibrates are hypolipidemic drugs which decrease cardiac events in individuals without raised levels of cholesterol. These drugs inhibit platelet function, but the mechanisms by which this pleiotropic effect is exerted are not known. METHODS AND RESULTS We used a range of approaches to show statins inhibit human platelet activation in vitro while engaging PPARalpha and P...
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عنوان ژورنال:
- Circulation research
دوره 98 5 شماره
صفحات -
تاریخ انتشار 2006